| 產品描述： | Pramlintide acetate(151126-32-8 free base) 是人胰島淀粉樣多肽的多肽類似物。它是一種抗糖尿病藥物，在結直腸癌中具有抗腫瘤作用。 |
| 體外研究： |
Pramlintide inhibited the growth of HCT-116 and HT-29 in a dose-dependent manner, with higher efficacy against the latter (IC50s; 48.67 and 9.10 μg/mL, respectively;?p-value =0.013). Moreover, the addition of 5, 10, and 20 μg/mL of pramlintide to HCT-116 and HT-29 with 5-fluorouracil, oxaliplatin, or irinotecan induced the antiproliferative effect synergistically (R>1.6,?p-value <0.05). |
| 參考文獻： |
1.Maha S Al-Keilani, et al. Pramlintide, an antidiabetic, is antineoplastic in colorectal cancer and synergizes with conventional chemotherapy. Clin Pharmacol. 2018 Mar 5;10:23-29. |
| 保存條件： |
-20°C |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
0.249 ml |
1.247 ml |
2.494 ml |
| 5 mM |
0.05 ml |
0.249 ml |
0.499 ml |
| 10 mM |
0.025 ml |
0.125 ml |
0.249 ml |
| 50 mM |
0.005 ml |
0.025 ml |
0.05 ml |
|
| 注意： |
部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學品經(jīng)營許可證（不帶存儲）
營業(yè)執(zhí)照(三證合一)
北京