| 產(chǎn)品描述： | PF-4708671 is a potent cell-permeable S6K1 inhibitor with a Ki of 20 nM and IC50 of 160 nM. |
| 靶點(diǎn)： |
S6K1：160 nM (IC50)；S6K1：20 nM (Ki)；S6K2：65 μM (IC50);S6Kinase;Autophagy |
| 體內(nèi)研究： |
The tumor growth rate in mice treated with the combination of OSI-906+PF-4708671 is significantly slower than that of OSI-906 alone (P=0.0189) or PF4708671 alone (P=0.0165) treated mice. The average tumor volume in the OSI-906+PF-4708671-treated mice is approximately 50% of that in mice treated with OSI-906 (P=0.0056) or PF-4708671 alone (P<0.001) at the end of a 15-day treatment |
| 參考文獻(xiàn)： |
1. Pearce LR, et al. Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem J. 2010 Oct 15;431(2):245-55. 2. Zhang Y, et al. Inhibition of p70S6K1 Activation by Pdcd4 Overcomes the Resistance to an IGF-1R/IR Inhibitor in Colon Carcinoma Cells. Mol Cancer Ther. 2015 Mar;14(3):799-809. |
| 溶解性： |
DMSO : 33.33 mg/mL (85.37 mM; Need ultrasonic) |
| 保存條件： |
-20℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.561 ml |
12.807 ml |
25.614 ml |
| 5 mM |
0.512 ml |
2.561 ml |
5.123 ml |
| 10 mM |
0.256 ml |
1.281 ml |
2.561 ml |
| 50 mM |
0.051 ml |
0.256 ml |
0.512 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
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