一本大道无码,麻豆文化传媒www网站入口,噜噜国产精品,亚洲高潮性爱免费久久视频

(+)-JQ-1 ( JQ1)

    
99%

(S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]

源葉(MedMol)
S80242 一鍵復(fù)制產(chǎn)品信息
1268524-70-4
C23H25ClN4O2S
456.99
3mxf; UNII-1MRH0IMX0W; 4flp;
貨號 規(guī)格 價格 上海 北京 武漢 南京 購買數(shù)量
S80242-1mg 99% ¥168.00 8 - - -
S80242-5mg 99% ¥320.00 6 - - -
S80242-10mg 99% ¥416.00 4 - - -
S80242-25mg 99% ¥760.00 6 - - -
S80242-50mg 99% ¥1040.00 4 - - -
S80242-100mg 99% ¥1520.00 7 - - -
S80242-500mg 99% ¥4800.00 6 - - -
產(chǎn)品介紹 參考文獻 質(zhì)檢證書(COA) 摩爾濃度計算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

(+)-JQ-1 (JQ1) is a potent, specific, and reversible BET bromodomain inhibitor, with IC50s of 77 and 33 nM for the first and second bromodomain (BRD4(1/2)). (+)-JQ-1 also activates autophagy

產(chǎn)品描述: (+)-JQ-1 (JQ1) is a potent, specific, and reversible BET bromodomain inhibitor, with IC50s of 77 and 33 nM for the first and second bromodomain (BRD4(1/2)). (+)-JQ-1 also activates autophagy
靶點: IC50: 77/33 nM (BRD4(1/2));EpigeneticReaderDomain;Autophagy;LigandsforTargetProteinforPROTAC
體內(nèi)研究: Matched cohorts of mice with established tumors are randomized to treatment with (+)-JQ1 (50 mg/kg) or vehicle, administered by daily intraperitoneal injection. Prior to randomization, and after four days of therapy, mice are evaluated by FDG-PET imaging. A marked reduction in FDG uptake is observed with (+)-JQ1 treatment. Tumor-volume measurements confirm a reduction in tumor growth with JQ1 treatment. Pharmacokinetic studies of (+)-JQ1 are performed in CD1 mice following intravenous and oral administration. Mean plasma concentration-time profiles of (+)-JQ1 after intravenous dosing (5 mg/kg). The pharmacokinetic parameters for intravenous (+)-JQ1 demonstrate excellent drug exposure (AUC=2090 hr*ng/mL) and an approximately one hour half-life (T1/2). Mean plasma concentration-time profiles of (+)-JQ1 after oral dosing (10 mg/kg). The pharmacokinetic parameters for oral (+)-JQ1 demonstrate excellent oral bioavailability (F=49%), peak plasma concentration (Cmax=1180 ng/mL) and drug exposure (AUC=2090 hr*ng/mL)
參考文獻: 1. Filippakopoulos P, et al. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73. 2. Sakamaki JI, et al. Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and LysosomalFunction. Mol Cell. 2017 May 18;66(4):517-532.e9. 3. Matzuk MM, et al. Small-molecule inhibition of BRDT for male contraception. Cell. 2012 Aug 17;150(4):673-84.
溶解性: DMSO  :  ≥  45  mg/mL  (98.47  mM)
保存條件: 2-8℃
配置溶液濃度參考:
1mg 5mg 10mg
1 mM 2.188 ml 10.941 ml 21.882 ml
5 mM 0.438 ml 2.188 ml 4.376 ml
10 mM 0.219 ml 1.094 ml 2.188 ml
50 mM 0.044 ml 0.219 ml 0.438 ml
注意: 部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的權(quán)威性,僅供客戶參考交流研究之用。

參考文獻

質(zhì)檢證書(COA)

如何獲取質(zhì)檢證書(COA)?
請輸入貨號和一個與之匹配的批號。
例如:
批號:JS298415 貨號:S20001-25g
在貨品標(biāo)簽上如何找到貨號和批號?

摩爾濃度計算器

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

=
×
×

相關(guān)產(chǎn)品