| 產(chǎn)品描述： | Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivit. Lopinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 14.2 μM |
| 靶點(diǎn)： |
HIV;HIV Protease;SARS-CoV;SARS-CoV;HIVProtease |
| 體內(nèi)研究： |
Coadministration with low-dose Ritonavir significantly improves the pharmacokinetic properties and hence the activity of Lopinavir against HIV-1 protease |
| 參考文獻(xiàn)： |
1. Cvetkovic RS, et al. Lopinavir/ritonavir: a review of its use in the management of HIV infection. Drugs. 2003;63(8):769-802. 2. Sham HL, et al. ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease. Antimicrob Agents Chemother. 1998;42(12):3218-3224. 3. Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212. |
| 溶解性： |
DMSO : 250 mg/mL (397.58 mM; Need ultrasonic) |
| 保存條件： |
2-8℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.59 ml |
7.952 ml |
15.903 ml |
| 5 mM |
0.318 ml |
1.59 ml |
3.181 ml |
| 10 mM |
0.159 ml |
0.795 ml |
1.59 ml |
| 50 mM |
0.032 ml |
0.159 ml |
0.318 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
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