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Tulathromycin A

    
98%

Tulathromycin A

源葉(MedMol)
S80543 一鍵復制產(chǎn)品信息
217500-96-4
C41H79N3O12
806.08
托拉菌素 A;托拉菌素A,土拉霉素A; 土拉霉素A; 土拉霉素 A;;(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[[2,6-Dideoxy-3-C-methyl-3-O-methyl-4-C-[(propylamino)methyl]-a-L-ribo-hexopyranosyl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,
貨號 規(guī)格 價格 上海 北京 武漢 南京 購買數(shù)量
S80543-5mg 98% ￥110.00 4 4 - -
S80543-10mg 98% ￥210.00 4 - - -
S80543-50mg 98% ￥700.00 2 - - -
S80543-100mg 98% ￥1210.00 7 - - -
S80543-1g 98% ￥4500.00 8 - - -
產(chǎn)品介紹 參考文獻 質(zhì)檢證書(COA) 摩爾濃度計算器 相關產(chǎn)品

產(chǎn)品介紹

Tulathromycin A (Tulathromycin), a macrolide antibiotic, inhibits protein synthesis (IC50=0.26 μM) by targeting bacterial ribosome. Tulathromycin A is used for the research of respiratory disease in cattle and swine. Immunomodulatory effects

產(chǎn)品描述： Tulathromycin A (Tulathromycin), a macrolide antibiotic, inhibits protein synthesis (IC50=0.26 μM) by targeting bacterial ribosome. Tulathromycin A is used for the research of respiratory disease in cattle and swine. Immunomodulatory effects
靶點： Macrolide;Antibacterial;Antibiotic
體內(nèi)研究： In the lungs of both A pleuropneumoniae- and zymosan-challenged pigs, Tulathromycin A (2.5 mg/kg, IM) promotes leukocyte apoptosis and efferocytosis and inhibites proinflammatory leukotriene B4 production, with a concurrent reduction in leukocyte necrosis relative to that of control pigs. Tulathromycin A also attenuates the degree of lung damage and lesion progression in A pleuropneumoniae-inoculated pigs
參考文獻： 1. Villarino N, et al. Pharmacokinetics of tulathromycin in healthy and neutropenic mice challenged intranasally with lipopolysaccharide from Escherichia coli. Antimicrob Agents Chemother. 2012;56(8):4078-4086. 2. Andersen NM, et al. Inhibition of protein synthesis on the ribosome by tildipirosin compared with other veterinary macrolides. Antimicrob Agents Chemother. 2012;56(11):6033-6036. 3. Duquette SC, et al. Immunomodulatory effects of tulathromycin on apoptosis, efferocytosis, and proinflammatory leukotriene B4 production in leukocytes from Actinobacillus pleuropneumoniae-or zymosan-challenged pigs. Am J Vet Res. 2015;76(6):507-519.
溶解性： DMSO  :  50  mg/mL  (62.03  mM;  Need  ultrasonic)
保存條件： -20℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 1.241 ml 6.203 ml 12.406 ml
5 mM 0.248 ml 1.241 ml 2.481 ml
10 mM 0.124 ml 0.62 ml 1.241 ml
50 mM 0.025 ml 0.124 ml 0.248 ml
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參考文獻

質(zhì)檢證書(COA)

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