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Selamectin

    
98%

Selamectin

源葉(MedMol)
S80548 一鍵復(fù)制產(chǎn)品信息
220119-17-5
C43H63NO11
769.967
司拉克丁;塞拉菌素;Selamectin;hypnocarpic acid;AverMectin A1a,25-cyclohexyl-4'-O-de(2,6-dideoxy-3-O-Methyl-a-L-arabino-hexopyranosyl)-5-deMethoxy-25-de(1-Methylpropyl)-22,23-dihydro-5-(hydroxyiMino)-,(5Z)-
貨號(hào) 規(guī)格 價(jià)格 上海 北京 武漢 南京 購(gòu)買數(shù)量
S80548-2mg 98% ¥200.00 >10 - - -
S80548-5mg 98% ¥300.00 >10 - - -
S80548-10mg 98% ¥500.00 >10 - - -
S80548-25mg 98% ¥1000.00 >10 - - -
S80548-100mg 98% ¥2400.00 >10 - - -
S80548-200mg 98% ¥3600.00 10 - - -
S80548-1g 98% ¥9600.00 2 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

Selamectin, a semi-synthetic macrocyclic lactone, is a potent parasiticide and anthelminthic. Selamectin activates glutamate-gated chloride channels in neurons and pharyngeal muscles to prevent heartworm, Lymphatic filariae, and nematode infection. Selamectin is also a potent P-glycoprotein substrate and a P-glycoprotein inhibitor with an IC50 of 120 nM

產(chǎn)品描述: Selamectin, a semi-synthetic macrocyclic lactone, is a potent parasiticide and anthelminthic. Selamectin activates glutamate-gated chloride channels in neurons and pharyngeal muscles to prevent heartworm, Lymphatic filariae, and nematode infection. Selamectin is also a potent P-glycoprotein substrate and a P-glycoprotein inhibitor with an IC50 of 120 nM
靶點(diǎn): Parasite;Chloride Channel;P-glycoprotein;Bacterial;Chloridechannel;P-gp;Parasite
體內(nèi)研究: A single administration of 6 mg/kg topical Selamectin given every two months could effectively prevent B. malayi infection in cats. Application of topical Selamectin twice a year could block circulating microfilariae
參考文獻(xiàn): 1. Patsharaporn T Sarasombath, et al. First study of topical selamectin efficacy for treating cats naturally infected with Brugia malayi and Brugia pahangi under field conditions. Parasitol Res. 2019 Apr;118(4):1289-1297. 2. J Griffin, et al. Selamectin is a potent substrate and inhibitor of human and canine P-glycoprotein. J Vet Pharmacol Ther. 2005 Jun;28(3):257-65.
溶解性: DMSO  :  ≥  100  mg/mL  (129.88  mM)
保存條件: -20℃
配置溶液濃度參考:
1mg 5mg 10mg
1 mM 1.299 ml 6.494 ml 12.988 ml
5 mM 0.26 ml 1.299 ml 2.598 ml
10 mM 0.13 ml 0.649 ml 1.299 ml
50 mM 0.026 ml 0.13 ml 0.26 ml
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參考文獻(xiàn)

質(zhì)檢證書(COA)

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批號(hào):JS298415 貨號(hào):S20001-25g
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摩爾濃度計(jì)算器

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