| 貨號(hào) | 規(guī)格 | 價(jià)格 | 上海 | 北京 | 武漢 | 南京 | 購(gòu)買(mǎi)數(shù)量 |
|---|---|---|---|---|---|---|---|
| S80619-2mg | 99% | ￥200.00 | 5 | - | - | - |
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| S80619-5mg | 99% | ￥270.00 | 6 | - | - | - |
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| S80619-10mg | 99% | ￥470.00 | 7 | - | - | - |
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| S80619-25mg | 99% | ￥970.00 | 5 | - | - | - |
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| S80619-50mg | 99% | ￥1850.00 | 貨期：2-3天 | - | - | - |
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| S80619-100mg | 99% | ￥2700.00 | 貨期：2-3天 | - | - | - |
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IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC50 of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth
| 產(chǎn)品描述： | IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC50 of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth | ||||||||||||||||||||
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| 靶點(diǎn)： | IC50: 26 nM (Notch);Gamma-secretase | ||||||||||||||||||||
| 體內(nèi)研究： | IMR-1 (i.p.; 15mg/kg; for 28 days) inhibits Notch-dependent tumor growth in patient-derived xenograft models. Animal Model: Nude mouses with adenocarcinoma xenograft Dosage: 15mg/kg Administration: I.p.; for 28 days Result: Blocks tumor establishment. | ||||||||||||||||||||
| 參考文獻(xiàn)： | 1. Astudillo L et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76(12):3593-603. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存條件： | -20℃ | ||||||||||||||||||||
| 配置溶液濃度參考： |
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| 注意： | 部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
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