一本大道无码,麻豆文化传媒www网站入口,噜噜国产精品,亚洲高潮性爱免费久久视频

BIIB021

    
98%

BIIB021

源葉(MedMol)
S80993 一鍵復(fù)制產(chǎn)品信息
848695-25-0
C14H15ClN6O
318.77
CNF2024;6-chloro-9-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-9H-purin-2-amine
貨號 規(guī)格 價格 上海 北京 武漢 南京 購買數(shù)量
S80993-5mg 98% ¥116.00 10 - - -
S80993-25mg 98% ¥350.00 8 - - -
S80993-50mg 98% ¥500.00 6 - - -
S80993-100mg 98% ¥700.00 1 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

BIIB021 (CNF2024) is an orally active, fully synthetic inhibitor of HSP90 with a Ki and an EC50 of 1.7 nM and 38 nM, respectively

產(chǎn)品描述: BIIB021 (CNF2024) is an orally active, fully synthetic inhibitor of HSP90 with a Ki and an EC50 of 1.7 nM and 38 nM, respectively
靶點: HSP90:1.7 nM (Ki);HSP90:38 nM (EC50);HSP;Autophagy
體內(nèi)研究: Oral administration of BIIB021 leads to tumor growth inhibition in many tumor xenograft models including N87, BT474, CWR22, U87, SKOV3 and Panc-1. BIIB021 effectively inhibits growth of L540cy tumor at a dose of 120 mg/kg. BIIB021 significantly enhances antitumor growth effect of radiation in JHU12 xenograf].
參考文獻(xiàn): 1. Lundgren, Karen., et al. BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Molecular Cancer Therapeutics (2009), 8(4), 921-929. 2. B?ll B, et al. Heat shock protein 90 inhibitor BIIB021 (CNF2024) depletes NF-kappaB and sensitizes Hodgkin's lymphoma cells for natural killer cell-mediated cytotoxicity. Clin Cancer Res. 2009 Aug 15;15(16):5108-16. 3. Yin X, et al. BIIB021, a novel Hsp90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy. Int J Cancer. 2010 Mar 1;126(5):1216-25 4. Zhang H, et al. BIIB021, a synthetic Hsp90 inhibitor, has broad application against tumors with acquired multidrug resistance. Int J Cancer. 2010 Mar 1;126(5):1226-34
溶解性: DMSO  :  ≥  45  mg/mL  (141.17  mM)
保存條件: -20℃
配置溶液濃度參考:
1mg 5mg 10mg
1 mM 3.137 ml 15.685 ml 31.371 ml
5 mM 0.627 ml 3.137 ml 6.274 ml
10 mM 0.314 ml 1.569 ml 3.137 ml
50 mM 0.063 ml 0.314 ml 0.627 ml
注意: 部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的權(quán)威性,僅供客戶參考交流研究之用。

參考文獻(xiàn)

質(zhì)檢證書(COA)

如何獲取質(zhì)檢證書(COA)?
請輸入貨號和一個與之匹配的批號。
例如:
批號:JS298415 貨號:S20001-25g
在貨品標(biāo)簽上如何找到貨號和批號?

摩爾濃度計算器

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

=
×
×

相關(guān)產(chǎn)品