| 產(chǎn)品描述： | PNU-74654 is an inhibitor of Wnt/β-catenin pathway with an IC50 of 129.8 μM in NCI-H295 cell. |
| 靶點： |
129.8 μM (Wnt/β-catenin, NCI-H295 cell);Apoptosis;?Wnt/beta-catenin |
| 參考文獻： |
1. Leal LF, et al. Inhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis. Oncotarget. 2015 Dec 15;6(40):43016-32. 2. Trosset JY, et al. Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening. Proteins. 2006 Jul 1;64(1):60-7. |
| 溶解性： |
DMSO : ≥ 30 mg/mL (93.65 mM) |
| 保存條件： |
-20℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.122 ml |
15.608 ml |
31.217 ml |
| 5 mM |
0.624 ml |
3.122 ml |
6.243 ml |
| 10 mM |
0.312 ml |
1.561 ml |
3.122 ml |
| 50 mM |
0.062 ml |
0.312 ml |
0.624 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學(xué)品經(jīng)營許可證（不帶存儲）
營業(yè)執(zhí)照(三證合一)
北京