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Solifenacin succinate

99%

Solifenacin succinate

產(chǎn)品說(shuō)明書核磁下載

品牌：源葉(MedMol)

產(chǎn)品編號(hào)：S81440 一鍵復(fù)制產(chǎn)品信息

CAS號(hào)：242478-38-2

分子式：C₂₃H₂₆N₂O·C₄H₆O₄

分子量：480.55

別名：Butanedioic acid, compd. with (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate (1:1)

貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S81440-10mg	99%	￥85.00 S81440-10mg ￥85.00 現(xiàn)貨	3700 >10	-	-	-
S81440-50mg	99%	￥127.50 S81440-50mg ￥127.50 現(xiàn)貨	748 >10	-	-	-
S81440-250mg	99%	￥195.50 S81440-250mg ￥195.50 現(xiàn)貨	157 >10	-	-	-
S81440-1g	99%	￥510.00 S81440-1g ￥510.00 現(xiàn)貨	46 >10	-	-	-

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產(chǎn)品介紹參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計(jì)算器相關(guān)產(chǎn)品

產(chǎn)品介紹

Solifenacin Succinate (YM905) is a novel muscarinic receptor antagonist with pKis of 7.6, 6.9 and 8.0 for M1, M2 and M3 receptors, respectively.

產(chǎn)品描述：

Solifenacin Succinate (YM905) is a novel muscarinic receptor antagonist with pKis of 7.6, 6.9 and 8.0 for M1, M2 and M3 receptors, respectively.

靶點(diǎn)：

mAChR;AChR

體內(nèi)研究：

Solifenacin Succinate (YM905) reduces bladder responses by 40% at a dose of 210 nmol/kg (0.1 mg/kg) and abolishes them at 2100 nmol/kg (1 mg/kg). In contrast, its inhibitory effects on salivary and cardiac responses are only slight at 630 nmol/kg (0.3 mg/kg), and reach 66% and 49%, respectively, at 2100 nmol/kg (1 mg/kg). At doses of 63 and 210 nmol/kg (0.03 and 0.1 mg/kg), Solifenacin Succinate slightly increases saliva secretion. Solifenacin Succinate (0.01 to 0.3 mg/kg i.v.) dose-dependently increases bladder capacity and voided volume at doses of 0.03 mg/kg i.v. or more, but does not affect residual volume or micturition pressure at any dose tested

參考文獻(xiàn)：

1. Krishna SR, Rao BM, Rao NS.A validated rapid stability-indicating method for the determination of related substances in solifenacin succinate by ultra-fast liquid chromatography.J Chromatogr Sci. 2010 Nov;48(10):807-10. 2. Ohtake A, Sato S, Sasamata M, Miyata K.The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: ameliorative effect of solifenacin succinate (Vesicare), a bladder-selective antimuscarinic agent, on overac 3. Hoffstetter S, Leong FC.Solifenacin succinate for the treatment of overactive bladder.Expert Opin Drug Metab Toxicol. 2009 Mar;5(3):345-50. 4. Choo MS, Lee JZ, Lee JB, Kim YH, Jung HC, Lee KS, Kim JC, Seo JT, Paick JS, Kim HJ, Na YG, Lee JG.Efficacy and safety of solifenacin succinate in Korean patients with overactive bladder: a randomised, prospective, double-blind, multicentre study.Int J Cli 5. Imamura T, et al.Combined treatment with a β3 -adrenergic receptor agonist and a muscarinic receptor antagonist inhibits detrusor overactivity induced by cold stress in spontaneously hypertensive rats. Neurourol Urodyn. 2017 Apr;36(4):1026-1033.

溶解性：

H2O : 100 mg/mL (208.09 mM; Need ultrasonic) DMSO : ≥ 100 mg/mL (208.09 mM)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.081 ml	10.405 ml	20.809 ml
5 mM	0.416 ml	2.081 ml	4.162 ml
10 mM	0.208 ml	1.04 ml	2.081 ml
50 mM	0.042 ml	0.208 ml	0.416 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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