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VCH-916

99%

VCH-916

產(chǎn)品說明書

品牌：源葉(MedMol)

產(chǎn)品編號：S82302 一鍵復(fù)制產(chǎn)品信息

CAS號：1200133-34-1

分子式：C₂₆H₃₆KNO₄S

分子量：497.73

別名：VCH 916; VCH-916||VCH 916; CS-1224;

貨號	規(guī)格	價格	上海	北京	武漢	南京	購買數(shù)量
S82302-5mg	99%	￥1500.00 S82302-5mg ￥1500.00 2-3天	0 貨期：2-3天	-	-	-
S82302-10mg	99%	￥2600.00 S82302-10mg ￥2600.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹參考文獻質(zhì)檢證書(COA) 摩爾濃度計算器相關(guān)產(chǎn)品

產(chǎn)品介紹

VCH-916 is a novel nonnucleoside HCV NS5B polymerase inhibitor. IC50 Value: Target: HCV VCH-916 is a novel allosteric inhibitor of HCV NS5B polymerase. The RNA-dependent RNA polymerase (NS5B) of HCV is one of the attractive validated targets for development of new drugs to block HCV infection. VCH-916 is currently being evaluated for safety/tolerability, pharmacokinetics and anti-viral efficacy in chronically infected HCV patient.

產(chǎn)品描述：

靶點：

HCV;HCVProtease

參考文獻：

1. Ludmila Gerber, Tania M. Welzel, Stefan Zeuzem. New therapeutic strategies in HCV: polymerase inhibitors. Liver International. 2013,33(s1): 85-92 2. Abdelrahman S. Mayhoub. Hepatitis C RNA-dependent RNA polymerase inhibitors: A review of structure-activity and resistance relationships; different scaffolds and mutations. Bioorganic & Medicinal Chemistry. 2012, 20 (10): 3150-3161. 3. Debasis Dasa, Jian Honga, Shu-Hui Chena, et al. Recent advances in drug discovery of benzothiadiazine and related analogs as HCV NS5B polymerase inhibitors. Bioorganic & Medicinal Chemistry. 2011, 19(16): 4690-4703 4. Pierre L Beaulieu. Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection. Informahealthcare. 2009, 19(2): 145-164 5. Safety,Tolerability and Pharmacokinetics of Multiple Ascending Doses of VCH 916 in Subjects With Chronic Hep C Infection

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.009 ml	10.046 ml	20.091 ml
5 mM	0.402 ml	2.009 ml	4.018 ml
10 mM	0.201 ml	1.005 ml	2.009 ml
50 mM	0.04 ml	0.201 ml	0.402 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

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摩爾濃度計算器

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