一本大道无码,麻豆文化传媒www网站入口,噜噜国产精品,亚洲高潮性爱免费久久视频

  1. 首頁 > 小分子化合物 > 信號通路 > 微生物學 > MUT056399

MUT056399

    
99%

MUT056399

源葉(MedMol)
S82673 一鍵復制產(chǎn)品信息
1269055-85-7
C15H13F2NO3
293.2654
4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzamide; 4-(4-ethyl-5-fluoro-2-hydroxy-phenoxy)-3-fluorobenzamide; MUT056399;
貨號 規(guī)格 價格 上海 北京 武漢 南京 購買數(shù)量
S82673-5mg 99% ￥2800.00 貨期：2-3天 - - -
S82673-10mg 99% ￥4800.00 貨期：2-3天 - - -
產(chǎn)品介紹 參考文獻 質(zhì)檢證書(COA) 摩爾濃度計算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

MUT056399 (Fab-001) is a highly potent inhibitor of the FabI enzyme of both S. aureus and E. coli with 50% inhibitory concentration IC50s of 12 nM and 58 nM, respectively.

產(chǎn)品描述： MUT056399 (Fab-001) is a highly potent inhibitor of the FabI enzyme of both S. aureus and E. coli with 50% inhibitory concentration IC50s of 12 nM and 58 nM, respectively.
靶點： IC50 value: 12 nM (for S. aureus), 58 nM (for E. coli);Antibacterial
體外研究： MUT056399 (Fab-001) is a highly potent new inhibitor of the FabI enzyme of both Staphylococcus aureus and Escherichia coli. MUT056399 is very active against S. aureus strains, including methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. aureus (MRSA), linezolid-resistant, and multidrug-resistant strains, with MIC90s between 0.03 and 0.12 μg/ml. MUT056399 is also active against coagulase-negative staphylococci, with MIC90s between 0.12 and 4 μg/ml. MUT056399 is very active against the 118 S. aureus strains tested, including MSSA and MRSA isolates and linezolid-resistant and multidrug-resistant strains, with MIC90s between ≤0.03 and 0.12 μg/ml.
體內(nèi)研究： MUT056399 (Fab-001), administered subcutaneously, protected mice from a lethal systemic infection induced by MSSA, MRSA, and vancomycin-intermediate S. aureus strains (50% effective doses ranging from 19.3 mg/kg/day to 49.6 mg/kg/day). In the nonneutropenic murine thigh infection model, the same treatment with MUT056399 reduced the bacterial multiplication of MSSA and MRSA in the thighs of immunocompetent mice.
參考文獻： 1. Escaich S, et al. The MUT056399 inhibitor of FabI is a new antistaphylococcal compound. Antimicrob Agents Chemother. 2011 Oct;55(10):4692-7. 2. Schiebel J, et al. An ordered water channel in Staphylococcus aureus FabI: unraveling the mechanism of substrate recognitionand reduction. Biochemistry. 2015 Mar 17;54(10):1943-55.
溶解性： soluble  in  DMSO
保存條件： -20℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 3.41 ml 17.049 ml 34.099 ml
5 mM 0.682 ml 3.41 ml 6.82 ml
10 mM 0.341 ml 1.705 ml 3.41 ml
50 mM 0.068 ml 0.341 ml 0.682 ml
注意： 部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

質(zhì)檢證書(COA)

如何獲取質(zhì)檢證書(COA)?
請輸入貨號和一個與之匹配的批號。
例如:
批號：JS298415 貨號：S20001-25g
在貨品標簽上如何找到貨號和批號?

摩爾濃度計算器

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

=
×
×

相關(guān)產(chǎn)品